Title

Intravenous oxygenator : enhancement of surface properties to minimize bubble size

Document Type

Thesis

Degree

Master of Science (MS)

Department

Biomedical Engineering

First Advisor's Name

Anthony McGoron

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Chenzhong Li

Third Advisor's Name

Roberto Panepucci

Date of Defense

2-28-2008

Abstract

Previous intravenous oxygenators relied on 02 diffusion to treat Acute Respiratory Distress Syndrome. However, bubble oxygenators may increase 02 transfer. Polypropylene and polysulfone hollow fiber membranes were modified using vapor graft polymerization (VGP) and solution graft polymerization (SGP) to decrease the pore size and porosity and increase the hydrophilicity of the fibers so that as 02 flowed through the treated fibers submerged in water the bubbles formed from the treated fiber would be smaller than those from pure fibers. Both methods increased the surface hydrophilicity; however, SGP decreased the fibers' porosity and pore sizes the most. After optimized VGP, 48% of polypropylene fibers' bubbles were 25-50 pm in radius, compared with 12% from pure polypropylene fibers. After optimized SGP, 38% of polysulfone fibers' bubbles were 25-50 pm in radius, compared with 21% from pure polysulfone fibers. However, treated polypropylene fibers required a pressure of 60 psig 02 to form bubbles.

Identifier

FI14060121

This document is currently not available here.

Share

COinS
 

Rights Statement

Rights Statement

In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/
This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).