Document Type

Dissertation

Degree

Doctor of Philosophy (PhD)

Department

Dietetics and Nutrition

First Advisor's Name

Fatma G. Huffman

First Advisor's Committee Title

Committee Chair

Second Advisor's Name

Zisca Dixon

Second Advisor's Committee Title

Committee Member

Third Advisor's Name

Vijaya Narayanan

Third Advisor's Committee Title

Committee Member

Fourth Advisor's Name

Tan Li

Fourth Advisor's Committee Title

Committee Member

Keywords

Inflammation, Adipocytokine, Metabolic Syndrome, Type 2 Diabetes, Haitian American, African American

Date of Defense

11-12-2014

Abstract

Chronic low-grade inflammation has been implicated in the processes leading to the development of type 2 diabetes (T2D) and its progression. Non-Hispanic Blacks bear a disproportionate burden of T2D and are highly susceptible to inflammation. This cross-sectional study assessed and compared the serum levels of established adipocytokines; interleukin-6 (IL-6), C-reactive protein (CRP), leptin, and novel adipocytokines; chemerin and omentin in Haitian and African Americans with and without T2D. The relationships of these adipocytokines with metabolic syndrome (MetS), anthropometric and HOMA2 measures by ethnicity and diabetes status were also assessed. Serum levels of IL-6, CRP, leptin, chemerin and omentin were determined by the ELISA method. HOMA2 measures were calculated for insulin sensitivity (HOMA2-IS) and insulin resistance (HOMA2-IR).

Analyses of available data for 230 Haitian Americans and 241 African Americans (240 with and 231 without T2D) for the first study showed that Haitian Americans with and without MetS had lower levels of IL-6 and CRP compared to African Americans with and without MetS (P

Ethnic-specific diabetes intervention and treatment programs must be designed to target Haitian Americans and African Americans as separate unique groups, in order to reduce the burden of T2D among the non-Hispanic Black community. Further research is needed to gain better understanding of the role of inflammation and T2D in this population.

Identifier

FI14110719

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