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Dehydroleucodin [systematic name: (1S,6S,2R)-9,13-dimethyl- 5-methylene-3-oxatricyclo[8.3.0.02,6]trideca-9,12-diene- 4,11-dione], C15H16O3, is a guanolide isolated from Artemisia douglasiana. The fused-ring system contains a sevenmembered ring that adopts a chair conformation, a fused planar cyclopentenone ring and a five-membered lactone ring fused in envelope conformation. The absolute structure determined by X-ray analysis agrees with that previously assigned to this compound by NMR studies [Bohlmann & Zdero (1972). Tetrahedron Lett. 13, 621–624] and also with that of leucodine, a closely related guaianolide [Martinez et al. (1988). J. Nat. Prod. 51, 221–228].
Priesta, Horacio A.; Abboud, Khalil A.; Velandia, Alvaro; Lopez, Luis A.; and Barbieri, Manuel Alejandro, "Dehydroleucodin: a guaiane-type sesquiterpene lactone" (2011). Department of Biological Sciences. 117.